Hool!gan's summary:

Mafia, four eyes, loli, ninja... All of them are alchemists?! Late 19th century, East End of London. It's the nest of the "Hooligans" (bastards). Lee Heartlib, an alchemist entrusted with the city by the previous generation, aims to create the ultimate "paradise" by alchemizing junkies to happiness!! Exhilarating and thrilling! The new best "HOOL" - a new alchemy battle action rules now!!